In this paper, an integrated electro-hydraulic braking system is designed through theoretical research and structural analysis, and the working characteristic and performance parameters of key components of the system are preliminarily determined by the analysis and calculation of the hydraulic system and its auxiliary mechanical system. A simulation model of the brake system is built by using AMESim software, and a simulation is conducted to verify the basic functions of the system. Furthermore, the influence of motor powers on the dynamic characteristics of the braking system is studied to obtain the best parameters of drive motor. Finally, a co-simulation on the overall performance of the braking system is carried out. The results show that the integrated electro-hydraulic braking system designed fully meets the braking requirements of intelligent driving vehicles, with all the indicators reaching and even exceeding the national standard.